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benzhydrocodone/acetaminophen and codeine equally boost sedation. Keep away from or Use Alternate Drug. Restrict use to patients for whom substitute therapy choices are insufficient
This medication might be taken with food items if tummy upset occurs. Drink an abundance of fluids when you are making use of this medication Except usually directed by your medical professional. The fluid might help loosen the mucus in the lungs.
Medications that have to have prior authorization. This restriction calls for that specific scientific conditions be met before the approval of the prescription.
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olanzapine/samidorphan decreases outcomes of codeine by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic outcomes and will increase danger of precipitating acute opioid withdrawal in individuals depending on opioids.
Dosage really should not be amplified if cough fails to respond; an unresponsive cough ought to be reevaluated in 5 days or quicker for attainable fundamental pathology, including foreign body or decreased respiratory tract condition
cimetidine will enhance the level or outcome of codeine by click here influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Observe. Stops conversion of codeine to its Energetic metabolite morphine.
Consult with a physician ahead of use If you're pregnant, nursing, taking drugs or have a medical condition.
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Reserve concomitant prescribing of those medicine in clients for whom other remedy options are inadequate. Limit dosages and durations to the bare minimum expected. Keep track of carefully for indications of respiratory depression and sedation.
abiraterone increases amounts of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Stay clear of coadministration of abiraterone with substrates of CYP2D6. If option therapy can not be applied, exercising caution and take into consideration a dose reduction with the CYP2D6 substrate.
Prevent using codeine in adolescents twelve to eighteen a long time of age who produce other chance components that may boost their sensitivity to respiratory depressant consequences of more info codeine; hazard factors include problems associated with hypoventilation, like postoperative position, obstructive slumber apnea, being overweight, critical pulmonary ailment, neuromuscular sickness, and concomitant usage of other medications that induce respiratory melancholy.